Epilepsy associated with brain tumors: mechanisms, clinical presentation and management
DOI:
https://doi.org/10.69789/cc.v18i2.774Keywords:
Epilepsy, Brain tumor, Surgery, EpileptogenesisAbstract
The objective of this review is to present a description of the current evidence for the evaluation and management of epilepsy in the population with brain tumor. Epilepsy is common in brain tumors, and between 30% and 70% of patients develop symptomatic epilepsy. This affects daily life even if the tumor is under control. There are various factors that affect the mechanism for the development of epileptogenesis. Such as type of tumor, location of the tumor, genetic peritumoral changes, surgery is one of the treatments that can contribute to reducing the symptoms of epilepsy and in turn treat the brain tumor and has shown high success rates with follow-up to long term.
References
Fisher RS, van Emde Boas W, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the ILAE and the IBE. Epilepsia [Internet]. 2005;46(4):470–2. Disponible en: http://dx.doi.org/10.1111/j.0013-9580.2005.66104.x
Maschio M. Brain tumor-related epilepsy. Curr Neuropharmacol [Internet]. 2012;10(2):124–33. Disponible en: http://dx.doi.org/10.2174/157015912800604470
van Breemen MS, Wilms EB, Vecht CJ. Epilepsy in patients with brain tumours: epidemiology, mechanisms, and management. Lancet Neurol [Internet]. 2007;6(5):421–30. Disponible en: http://dx.doi.org/10.1016/S1474-4422(07)70103-5
Englot DJ, Chang EF, Vecht CJ. Epilepsy and brain tumors. Handb Clin Neurol [Internet]. 2016;134:267–85. Disponible en: http://dx.doi.org/10.1016/B978-0-12-802997-8.00016-5
Yuen TI, Morokoff AP, Bjorksten A, et al. Glutamate is associated with a higher risk of seizures in patients with gliomas. Neurology [Internet]. 2012;79(9):883–9. Disponible en: http://dx.doi.org/10.1212/WNL.0b013e318266fa89
Klinger N, Shah A, Mittal S. Management of brain tumor–related epilepsy. Neurol India [Internet]. 2017;65(Suppl 7):S60–70. Disponible en: http://dx.doi.org/10.4103/0028-3886.205009
Blümcke I, Aronica E, Urbach H, et al. A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology of LEAT. Acta Neuropathol [Internet]. 2014;128(1):39–54. Disponible en: https://doi.org/10.1007/s00401-014-1288-9
Ertürk Çetin Ö, İşler C, Uzan M, Özkara Ç. Epilepsy-related brain tumors. Seizure [Internet]. 2017;44:93–7. Disponible en: http://dx.doi.org/10.1016/j.seizure.2016.12.012
Kerkhof M, Vecht CJ. Seizure characteristics and prognostic factors of gliomas. Epilepsia [Internet]. 2013;54(Suppl 9):12–7. Disponible en: http://dx.doi.org/10.1111/epi.12437
Chang EF, Potts MB, Keles GE, et al. Seizure characteristics and seizure control following resection in 332 patients with low-grade gliomas. J Neurosurg [Internet]. 2008;108(2):227–35. Disponible en: http://dx.doi.org/10.3171/JNS/2008/108/2/0227
Wychowski T, Wang H, Buniak L, et al. Considerations in prophylaxis for tumor-associated epilepsy. Clin Neurol Neurosurg [Internet]. 2013;115(11):2365–9. Disponible en: http://dx.doi.org/10.1016/j.clineuro.2013.08.023
Chaichana KL, Parker SL, Olivi A, Quinones-Hinojosa A. Long-term seizure outcomes after primary resection of malignant brain astrocytomas. J Neurosurg [Internet]. 2009;111(2):282–92. Disponible en: https://doi.org/10.3171/2009.2.JNS081132
Luyken C, Blümcke I, Fimmers R, et al. Long-term epilepsy-associated tumors: seizures and tumor outcome. Epilepsia [Internet]. 2003;44(6):822–30. Disponible en: http://dx.doi.org/10.1046/j.1528-1157.2003.56102.x
Campos MG. Tumores cerebrales asociados a epilepsia. Rev Med Clin Condes [Internet]. 2017;28(3):390–8. Disponible en: http://dx.doi.org/10.1016/j.rmclc.2017.05.008
You G, Sha Z, Jiang T. The pathogenesis of tumor-related epilepsy and its implications for clinical treatment. Seizure [Internet]. 2012;21(3):153–9. Disponible en: http://dx.doi.org/10.1016/j.seizure.2011.12.016
Southwell DG, García PA, Berger MS, et al. Long-term seizure control outcomes after resection of gangliogliomas. Neurosurgery [Internet]. 2012;70(6):1406–14. Disponible en: http://dx.doi.org/10.1227/NEU.0b013e3182500a4c
Núñez-Herrera E, Núñez-Villadiego J, Peña-Pinzón S, Albarracín-Albarracín Y. Tumores encefálicos asociados con epilepsia. Acta Neurol Colomb [Internet]. 2022;38(2):66–70. Disponible en: http://dx.doi.org/10.22379/24224022408
Cook WH, Gillespie CS, Bakhsh A, et al. Epileptogenesis in meningioma: theories, biomarkers, and postoperative risk. Epilepsia [Internet]. 2025;65(1):e8559. Disponible en: http://dx.doi.org/10.1111/epi.18559
Gruber MD, Pindrik J, Damante M, et al. Epileptic versus neuro-oncological focus in pediatric lesions with seizures: systematic review. J Neurosurg Pediatr [Internet]. 2023;32(5):576–83. Disponible en: http://dx.doi.org/10.3171/2023.6.PEDS22440
Guerrini R, Rosati A, Giordano F, et al. Medical and surgical treatment of tumoral seizures. Epilepsia [Internet]. 2013;54 Suppl 9:84–90. Disponible en: http://dx.doi.org/10.1111/epi.12450
Khalili BF, Chojnacki MR, Dixit K, et al. Surgical treatment of brain tumor-related epilepsy: current and emerging strategies. Cancers (Basel) [Internet]. 2025;17(21):3539. Disponible en: http://dx.doi.org/10.3390/cancers17213539
Politsky JM. Brain tumor-related epilepsy: etiologic basis and treatment approaches. Curr Neurol Neurosci Rep [Internet]. 2017;17(9):70. Disponible en: http://dx.doi.org/10.1007/s11910-017-0777-3
Sokolov E, Dietrich J, Cole AJ. Epilepsy in people with glioblastoma: complexities and mechanisms. Lancet Neurol [Internet]. 2023;22(6):505–16. Disponible en: http://dx.doi.org/10.1016/S1474-4422(23)00031-5
Vecht CJ, Royer-Perron L, Houillier C, Huberfeld G. Seizures and anticonvulsants in brain tumours. Curr Pharm Des [Internet]. 2017;23(42):6464–77. Disponible en: http://dx.doi.org/10.2174/1381612823666171027130003
Hamer HM, de Curtis M, Lopes da Silva FH. Tumor-related epilepsy: diagnostic and therapeutic approaches. Nat Rev Neurol [Internet]. 2024;20(1):45–60.
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